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ORIGINAL ARTICLE
Year : 2019  |  Volume : 32  |  Issue : 3  |  Page : 124-130

Hepatic expression of integrin β-8 protein as a risk factor in infants with biliary atresia


1 Department of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Menoufia, Egypt
2 Department of Pathology, National Liver Institute, Menoufia University, Menoufia, Egypt

Correspondence Address:
Nermin M Adawy
Department of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Menoufia, National Liver Institute 32511
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/AJOP.AJOP_7_20

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Introduction Biliary atresia (BA) is a progressive obliteration of the extrahepatic bile ducts that affects as many as 1 in 5000 children in certain areas of the world. Aim The aim was to study the expression of integrin β-8 in patients with BA and compare it with patients with non-BA cholestasis. Patients and methods This study was conducted on 30 infants with BA and 30 infants with cholestasis other than BA. Integrin β-8 immunohistochemical (IHC) staining was done to all studied groups. Results In this study, infants with BA had statistically significant more integrin β-8 expression than non-BA patients (P=0.001) with significantly higher expression at IHC score 3 (P<0.0001). While non-BA infants had significantly higher expression at low IHC score 1 (P<0.0001) integrin β-8 IHC score at a cutoff value greater than 2 could discriminate between BA and non-BA groups that had 0.729 area under the receiver-operating characteristic curve with 83.3% sensitivity, 60% specificity, and 71.6% accuracy. Conclusion Integrin β-8 expression is significantly more expressed in patients with BA than non-BA patients and can significantly discriminate BA at an IHC score of greater than 2 from other causes of neonatal cholestasis.


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