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ORIGINAL ARTICLE
Year : 2019  |  Volume : 32  |  Issue : 1  |  Page : 19-26

Predictive value of neutrophil gelatinase-associated lipocalin and E-selectin in pediatric sepsis


1 Department of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Correspondence Address:
Hanan A El-Sattar El-Halaby
Department of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura Gomheria Street, Mansoura 35516
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/AJOP.AJOP_11_19

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Background Sepsis is a leading cause of death in infants and children; early prediction could save patients’ lifes. Aim The aim of this study was to explore the role of neutrophil gelatinase-associated lipocalin (NGAL) and E-selectin in measurements in diagnosing and predicting mortality in patients with suspected sepsis and to identify whether their concentrations differ with blood culture results. Patients and methods This is a two-phase study; the first is a comparative and the second is a cross-sectional one, performed in Mansoura University Children’s Hospital from January to December 2017. The study involved100 children with clinically suspected sepsis and 40 healthy children (the control group). NGAL, E-selectin, C-reactive protein, total leukocyte count, and blood culture were assessed. Patient survival was recorded within 30 days of hospital admission. The study was performed after local institutional review board approval. For parametric data, t-test was used and for threshold value detection receiver operating characteristic curves were used. Results Significantly higher NGAL, E-selectin, C-reactive protein, and total leukocyte count levels were recorded in patients with clinically suspected sepsis than healthy participants; also, they were significantly higher in nonsurvivors. receiver operating characteristic curves for 30-day patients’ mortality showed E-selectin was a good discriminator (area under the curve=0.841), whereas area under the curve was 0.667 for NGAL. E-selectin was significantly higher in the culture-positive group (P=0.012), whereas NGAL did not differ significantly (P=0.153). Conclusion E-selectin and NGAL are diagnostic markers for sepsis. E-selectin is a sensitive prognostic biomarker in patients with clinically suspected sepsis whereas NGAL is less sensitive. E-selectin is significantly higher in blood culture-positive patients with sepsis whereas NGAL did not differ significantly.


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