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Year : 2018  |  Volume : 31  |  Issue : 1  |  Page : 1-7

Studying a possible relationship among serum leptin, serum zinc and BMI in children

1 Regional Center for Food and Feed, Agriculture Research Center, Alexandria, Egypt
2 Department of Pediatrics, Faculty of Medicine, Alexandria University, Alexandria, Egypt
3 Department of Chemical Pathology, Medical Research Institute, Alexandria University, Alexandria, Egypt
4 Family and Community Medicine Department, Faculty of Medicine, Benghazi University, Benghazi, Libya

Correspondence Address:
Lamia M Hafez
Regional Center for Food and Feed-Agriculture Research Center, Alexandria 21616
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/AJOP.AJOP_7_18

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Background Developing countries are facing the double burden of nutritional transition, malnutrition and micronutrient deficiencies, as well as a rapidly growing epidemic of childhood obesity. Leptin is a key hormone in the regulation of BMI, and a relation between zinc and leptin was detected. Aim This study aimed to investigate the relationship among serum leptin, serum zinc and BMI in children. Patients and methods A cross-sectional study was carried out on a total of 82 children of both sexes aged from 2 to 14 years attending the outpatient clinic at Alexandria University Children’s Hospital, Egypt, over 3 months from September 2016 to November 2016. All participants were clinically evaluated for weight, height and BMI. Serum leptin and serum zinc were measured. Results From the total sample of 82 children, it was found that the high percent of overweight children were found in the age group between 9 and at least 14 in both sexes (48% in boys and 37.5% in girls). The mean serum leptin level was insignificantly higher in girls in the age group from 9 to up to 14 years; it was 10.67 μg in girls, whereas it was 9.0 in boys. There was no significant difference in serum zinc level between boys and girls at all age groups. There was an insignificant negative correlation between serum leptin and serum zinc in boys and girls at all age groups. The correlation between serum leptin and BMI was significantly positive in girls at age group 9 to up to 14 years (r=0.644, P=0.013). Serum zinc was insignificantly negatively correlated with BMI in boys and girls at age group 9 to up to 14 years, but the relation was positively significant in boys in the age group 2 to less than 3 (r=0.757, P=0.049). Conclusion The correlation between leptin and BMI in girls was significant at age group 9 to up to 14 years. A negative insignificant correlation was found between serum leptin and serum zinc. Insignificant positive correlation was found between serum zinc and BMI.

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